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    Los Angeles Chargers @ Buffalo Bills

    LAC
    Los Angeles ChargersChargersLAC
    0-2, 0-0 Away
    BUF
    Buffalo BillsBillsBUF
    2-0, 1-0 Home
    • Gamecast
    • Preview
    • Videos
    • Odds
    • TicketsLatest 401872953 - ESPN News

    Game Odds
    Odds by

    2026-09-27T17:00ZOpenSpreadTotalML
    Los Angeles ChargersLos Angeles ChargersLAC
    (0-2)
    (0-2)
    o48.5
    -110
    +7
    -105
    o50.5
    -102
    +275
    Buffalo BillsBuffalo BillsBUF
    (2-0)
    (2-0)
    -2.5
    -110
    -7
    -115
    u50.5
    -118
    -345
    See More Odds

    Recent Schedule

    DATEOPPRESULTSPREADTOTAL
    9/20vsLVL26-14-6.543.5
    9/13vsARIL26-14-8.547.5
    8/27vsLARL20-18-3.537.5
    8/20vsSFL41-17-1.538.5
    8/13@HOUW27-7+1.538.5

    Matchup Predictor

    Los Angeles Chargers
    Buffalo Bills
    21.7
    %

    LAC

    78.1
    %

    BUF

    According to ESPN Analytics

    Betting 101

    The Beginner's Guide to BettingReady to enter the world of sports betting? Here's everything you need to know to get started.
    James Cook III
    BUF RB
    Josh Allen
    BUF QB
    Omarion Hampton
    LAC RB
    Dalton Kincaid
    BUF TE
    DJ Moore
    BUF WR
    Khalil Shakir
    BUF WR
    Ladd McConkey
    LAC WR
    Oronde Gadsden
    LAC TE
    FIRST TD
    Anytime TD
    2+ TDs
    +400
    -185
    +300
    +550
    -140
    +380
    +600
    -130
    +450
    +950
    +170
    +1300
    +1000
    +165
    +1300
    +1200
    +210
    +1700
    +1500
    +195
    +1600
    +1800
    +250
    +2200
    See More Odds
    Josh Allen
    BUF QB
    Justin Herbert
    LAC QB
    o239.5
    -113
    u239.5
    -111
    o226.5
    -113
    u226.5
    -111
    See More Odds
    James Cook III
    BUF RB
    Omarion Hampton
    LAC RB
    Josh Allen
    BUF QB
    Justin Herbert
    LAC QB
    o80.5
    -110
    u80.5
    -114
    o58.5
    -112
    u58.5
    -112
    o34.5
    -110
    u34.5
    -115
    o19.5
    -112
    u19.5
    -112
    See More Odds
    Ladd McConkey
    LAC WR
    Dalton Kincaid
    BUF TE
    DJ Moore
    BUF WR
    Khalil Shakir
    BUF WR
    Oronde Gadsden
    LAC TE
    Quentin Johnston
    LAC WR
    o60.5
    -110
    u60.5
    -114
    o57.5
    -114
    u57.5
    -110
    o49.5
    -114
    u49.5
    -110
    o39.5
    -113
    u39.5
    -111
    o37.5
    -113
    u37.5
    -111
    o35.5
    -115
    u35.5
    -109
    See More Odds
    Buffalo Bills
    2-0
    Los Angeles Chargers
    0-2
    o19.5
    -750
    u19.5
    +500
    o10.5
    -750
    u10.5
    +500
    See More Odds

    Injury Report

    Los Angeles Chargers
    NameStatus
    Rodney ShelleyR. ShelleyCB
    QuestionableHamstring
    Trey Pipkins IIIT. Pipkins IIIOT
    OutKnee
    Kayode AwosikaK. AwosikaG
    OutLower Leg
    Dalvin TomlinsonD. TomlinsonDT
    OutHamstring
    Elijah MoldenE. MoldenCB
    OutHamstring
    Buffalo Bills
    NameStatus
    Ed OliverE. OliverDT
    QuestionableHip
    Keon ColemanK. ColemanWR
    QuestionableAnkle
    DJ MooreD. MooreWR
    QuestionableShoulder - AC Joint
    Ar'maj Reed-AdamsA. Reed-AdamsG
    QuestionableElbow
    T.J. SandersT.J. SandersDT
    Out
    Full Injury Report

    Super Bowl Winner

    TEAMODDS
    LARLAR+620
    BUFBUF+750
    BALBAL+950
    SEASEA+1000
    SFSF+1050
    KCKC+1100
    PHIPHI+1600
    CINCIN+1700
    TEAMODDS
    DETDET+2000
    NENE+2000
    DENDEN+2000
    HOUHOU+2200
    DALDAL+2400
    JAXJAX+2500
    MINMIN+2600
    CHICHI+3000
    See More NFL Futures
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