Arizona Cardinals @ San Francisco 49ers

1-1, 1-0 Away

2-0, 1-0 Home

49ers coach Kyle Shanahan faces another disciple in game against Cardinals coach Mike LaFleur

— San Francisco 49ers coach Kyle Shanahan said he might appreciate one day how many assistants that used to work under him have become head coaches in the NFL.

Sep 24, 2026, 05:32 pm - AP

Season Leaders

ARI

Passing Yards

Rushing Yards

Receiving Yards

Sacks

Tackles

Injury Report

Arizona Cardinals

Name	Status	Est. Return
Roy LopezR. LopezDT	QuestionableGroin	Sep 27
Max MeltonM. MeltonCB	QuestionableToe	Sep 27
Dadrion Taylor-DemersonD. Taylor-DemersonS	OutBack	Oct 4
Will JohnsonW. JohnsonCB	IRNeck	Feb 15
Kitan CrawfordK. CrawfordS	IRAnkle	Oct 18

San Francisco 49ers

Name	Status	Est. Return
James Thompson Jr.J. Thompson Jr.DT	OutAnkle	Oct 4
Romello HeightR. HeightDE	OutHand	Oct 4
Nick BosaN. BosaDE	OutCalf	Oct 4
Mike EvansM. EvansWR	QuestionableHip	Sep 27
C.J. WestC.J. WestDT	IRUndisclosed	Oct 25

Cardinals

DATE	OPP	RESULT
9/20/26	vsSEA	L31-7
9/13/26	@LAC	W26-14
8/28/26	@GB	L42-38
8/22/26	vsDAL	L34-13
8/13/26	@LV	W27-14

49ers

DATE	OPP	RESULT
9/20/26	vsMIA	W35-13
9/10/26	vsLAR	W27-7
8/27/26	@LV	W18-12
8/20/26	@LAC	W41-17
8/13/26	vsTEN	L19-13

Data is currently unavailable.

2026-09-27T20:05ZOpenSpreadTotalML

Arizona CardinalsCardinalsARI

(1-1)

(1-1, 1-0 Away)

o46.5

-110

San Francisco 49ers49ersSF

(2-0)

(2-0, 1-0 Home)

-11.5

-110

49ers vs CardinalsLevi's Stadium - Sun 9/27/26, 4:05Tickets as low as $92

Buy 49ers tickets with VividSeats

National Football Conference

NFC West	W	L	PCT	PF	PA
Seattle	2	0	1.000	44	17
San Francisco	2	0	1.000	62	20
Los Angeles	1	1	.500	35	33
Arizona	1	1	.500	33	45

NFL News

Eagles' Saquon Barkley to be 'fearless' vs. Bears despite stinger

Eagles running back Saquon Barkley plans to play "fearless" Monday night against the Chicago Bears as he eyes a return from a stinger injury.

QB Sam Darnold back Sunday, but Seahawks down two safeties

Seahawks quarterback Sam Darnold will start Sunday, but the defending Super Bowl champions will be without both starting safeties as Julian Love and Ty Okada have been ruled out.

Jayden Daniels avoids IR after elbow injury

Ian Rapoport shares encouraging news on Jayden Daniels' elbow injury, with the Commanders hopeful their quarterback will return sooner rather than later.

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